The Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS) program was launched in 2015 to develop sensor-based, integrated health monitoring systems for measuring environmental, physiological, and behavioral factors in pediatric epidemiological studies of asthma, and eventually other chronic diseases.The following three arms of the PRISMS Program will be closely aligned to ensure functionality of the overall program.
Sensor Development Projects for Asthma: Researchers will develop wearable and non-wearable sensors that can monitor pediatric environmental exposures, physiological signals, activity, and/or behavior in a natural environment. They will pursue new insights into environmental determinants of asthma. These new, existing, or redesigned sensors will plug and play—physically or wirelessly—with the PRISMS informatics platforms.
Informatics Platform Technologies for Asthma: Researchers will develop informatics platforms that will enable data acquisition from environmental, physiological, and behavior sensors. These platforms will integrate, process, and visualize data, and will provide secure uploading of results to the PRISMS data and software coordination and integration center.
Data and Software Coordination and Integration Center: Researchers will develop a center to coordinate and integrate outputs from the Informatics Technology Platform Centers. The Center will coordinate and integrate data and ensure consistent annotation of data and tools generated within the PRISMS program. It will incorporate relevant non-PRISMS data into the PRISMS resource; support integration of relevant data and tools to allow for seamless exploration of the PRISMS program’s output by a broad range of biomedical researchers; support linkages to outside knowledge bases, data portals, and resources; support training in integrated sensor monitoring data science skills; build innovative access and query tools to disparate databases hosting multiple data types; and disseminate the resulting tools and resources to the broad range of biomedical researchers.
Learn more about the program at the PRISMS website.
NIH awarded the following PRISMS grants in September 2015 (pending available funds):
PRISMS Data and Software Coordination and Integration Center (DSCIC)
University of Southern California, Los Angeles, $5.25 million, four years
Principal Investigators: Jose-Luis Ambite, Ph.D., and Frank Gilliland, M.D., Ph.D.
PRISMS Informatics Platform-Federated Integration Platform
University of Utah, Salt Lake City, $5.53 million, four years
Principal Investigator: Katherine Sward, Ph.D.
The Los Angeles PRISMS Center: The Biomedical REAl-Time Health Evaluation (BREATHE) Platform
University of California, Los Angeles, $6.09 million, four years
Principal Investigator: Alex Bui, Ph.D.
A Wearable Monitor for Pediatric Asthma: Developing Environmental and Breath Sensors Linked to Spirometry
University of California, Davis, $1.45 million, four years
Principal Investigators: Cristina Davis, Ph.D., and Nicholas Kenyon, Ph.D.
Development of the Total Exposure Monitoring Unit (TEMU) for Pediatric Asthma
University of Washington, Seattle, $1.76 million, four years
Principal Investigator: Edmund Seto, Ph.D.
Ambulatory Sensor Arrays for Real-Life Monitoring of Pediatric Patients with Asthma
George Washington University, $2.02 million, four years
Principal Investigator: Zhenyu Li, Ph.D.
Monitoring Particulate, PAH, Allergen and Microbial Exposures in Asthmatic Kids
Columbia University, New York, $1.98 million, four years
Principal Investigators: Steven Chillrud, Ph.D., and Matthew Perzanowski, Ph.D.
A Personal Exposure and Response Monitoring System for Pediatric Asthma Study
Arizona State University, Tempe , $1.96 million, four years
Principal Investigator: Nongjian Tao, Ph.D.
A Wearable Asthma Trigger Monitoring System with Integrated Physiological Monitor
University of Maryland Baltimore County, Baltimore, $1.96 million, four years
Principal Investigators: Yordan Kostov, Ph.D., Alicia Meuret, Ph.D., Govind, Rao, Ph.D., and Thomas Ritz, Ph.D.