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High-resolution Gamma Imager for Small Animal Imaging of Radioisotopes for Cancer Treatment
Collaborators
Peter Choyke, M.D.
Molecular Imaging Program, Center for Cancer Research, NCI
Jurgen Seidel, Ph.D.
Molecular Imaging Program, Center for Cancer Research, NCI
Michael Green, Ph.D.
Molecular Imaging Program, Center for Cancer Research, NCI
Wenze Xi, Ph.D.
Radiation Detector and Medical Imaging Group, Thomas Jefferson National Accelerator Facility
Project Brief
SPIS collaborated with NCI’s Molecular Imaging Program (MIP) to develop novel imaging systems used in the development of radionuclide-labeled compounds. Successfully developed radionuclide-labeled compounds offer the ultimate prospect of PET, SPECT and planar imaging in human subjects for medical diagnostic and management purposes. Equally powerful applications exist in basic science when used for probe validation in small laboratory animals.
Two examples of this latter kind were the focus of SPIS/MIP projects: (1) development of the MONICA (Mobile Nuclear Imaging Cameras) dual planar gamma camera system for visualizing and analyzing the whole-body bio-distribution of putative diagnostic and therapeutic single photon emitting radiotracers in animals the size of mice, and (2) a portable positron projection imaging system (PPI) capable of these same tasks but optimized for imaging positron-labeled compounds.
MONICA is a turnkey portable system comprised of two side-by-side flat panel detectors, support electronics, and software providing the ability to rapidly obtain a projection image in mice. SPIS developed custom electronics to interface with the position-sensitive photomultiplier tubes (PSPMT), including the row-column readout electronics, amplifiers, and power sub-system for the low-voltage amplifier boards and the high-voltage PSPMTs. SPIS also developed software to integrate multiple commercial data acquisition devices with the NucLear Mac, a hardware and software platform commonly used in clinical gamma camera applications. This NucLear Mac-based design provides the end user with a familiar user interface (e.g., data processing functions) while using the highly-customized MONICA system.
Capitalizing on this successful detector design, the team proceeded to develop a complimentary system for use with positron-emitting compounds. The PPI front-end has recently been converted to a portable, stand-alone system for imaging mice at remote locations and for tissue-section imaging, an application made possible by changing the distance between detector modules.