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Maria A Aronova

Maria Aronova
Maria A Aronova ,
Ph.D.
Staff Scientist
Labs/Section:
Cellular and Supramolecular Structure and Function
301-451-3858
aronovaa@mail.nih.gov
Biography

Dr. Aronova received her Ph.D. degree in 2004 from the Physics Department at the University of Maryland in College Park. Her doctoral dissertation involved the design of novel multifunctional magnetic and electronic materials using different thin film technologies, which involved development of imaging techniques for characterizing the magnetic properties of those materials. In 2005, Dr. Aronova joined LCIMB, NIBIB, to develop compositional imaging techniques based on electron energy loss spectroscopy and energy-filtered transmission electron microscopy (EFTEM).  Dr. Aronova has combined EFTEM with electron tomography to obtain the first 3D distributions of chemical elements in cells.  She has also been using the techniques to characterize the composition and structure of theranostic bionanoparticles.

Publications
Densely Populated Cell and Organelles Segmentation with U-Net Ensembles.
Fulton SJBaenen CMStorrie BYang ZLeapman RDAronova MA
bioRxiv
2025 Jan 07

Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets.
Matharu SSNordmann CSOttman KRAkkem RPalumbo DCruz DRDCampbell KSievert GSturgill JPorterfield JZJoshi SAlfar HRPeng CPokrovskaya IDKamykowski JAWood JPGarvy BAronova MAWhiteheart SWLeapman RDStorrie B
Platelets
2023 Dec

Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis.
Joshi SSmith ANPrakhya KSAlfar HRLykins JZhang MPokrovskaya IAronova MLeapman RDStorrie BWhiteheart SW
J Vis Exp
2023 Mar 17

Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site.
Pokrovskaya IDRhee SWBall KKKamykowski JAZhao OSCruz DRDCohen JAronova MALeapman RDStorrie B
Res Pract Thromb Haemost
2023 Feb

Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines.
Chen XCrosby KCFeng APurkey AMAronova MAWinters CACrocker VTLeapman RDReese TSDell'Acqua ML
Front Synaptic Neurosci
2022

Placozoan fiber cells: mediators of innate immunity and participants in wound healing.
Mayorova TDHammar KJung JHAronova MAZhang GWinters CAReese TSSmith CL
Sci Rep
2021 Dec 02

Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates.
Rhee SWPokrovskaya IDBall KKLing KVedanaparti YCohen JCruz DRDZhao OSAronova MAZhang GKamykowski JALeapman RDStorrie B
Commun Biol
2021 Sep 16

Use of dual-electron probes reveals the role of ferritin as an iron depot in erythropoiesis.
Aronova MANoh SJZhang GByrnes CMeier ERKim YCLeapman RD
iScience
2021 Aug 20

Biphasic synthesis of biodegradable urchin-like mesoporous organosilica nanoparticles for enhanced cellular internalization and precision cascaded therapy.
Cheng YJiao XWang ZJacobson OAronova MAMa YHe LLiu YTang WDeng LZou JYang ZZhang MWen YFan WChen X
Biomater Sci
2021 Apr 07

Dense cellular segmentation for EM using 2D-3D neural network ensembles.
Guay MDEmam ZASAnderson ABAronova MAPokrovskaya IDStorrie BLeapman RD
Sci Rep
2021 Jan 28

Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape.
Pokrovskaya ITobin MDesai RAronova MAKamykowski JAZhang GJoshi SWhiteheart SWLeapman RDStorrie B
Platelets
2021 Jul 04

Canalicular system reorganization during mouse platelet activation as revealed by 3D ultrastructural analysis.
Pokrovskaya IDTobin MDesai RJoshi SKamykowski JAZhang GAronova MAWhiteheart SWLeapman RDStorrie B
Platelets
2021 Jan 02

3D ultrastructural analysis of α-granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets.
Pokrovskaya IDYadav SRao AMcBride EKamykowski JAZhang GAronova MALeapman RDStorrie B
Res Pract Thromb Haemost
2020 Jan

Precision Cancer Theranostic Platform by In Situ Polymerization in Perylene Diimide-Hybridized Hollow Mesoporous Organosilica Nanoparticles.
Yang ZFan WZou JTang WLi LHe LShen ZWang ZJacobson OAronova MARong PSong JWang WChen X
J Am Chem Soc
2019 Sep 18

Wet/Sono-Chemical Synthesis of Enzymatic Two-Dimensional MnO Nanosheets for Synergistic Catalysis-Enhanced Phototheranostics.
Tang WFan WZhang WYang ZLi LWang ZChiang YLLiu YDeng LHe LShen ZJacobson OAronova MAJin AXie JChen X
Adv Mater
2019 May

Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy.
Fan WLu NShen ZTang WShen BCui ZShan LYang ZWang ZJacobson OZhou ZLiu YHu PYang WSong JZhang YZhang LKhashab NMAronova MALu GChen X
Nat Commun
2019 Mar 18

SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets.
Pokrovskaya IDJoshi STobin MDesai RAronova MAKamykowski JAZhang GWhiteheart SWLeapman RDStorrie B
Blood Adv
2018 Nov 13

Dotted Core-Shell Nanoparticles for T -Weighted MRI of Tumors.
Shen ZSong JZhou ZYung BCAronova MALi YDai YFan WLiu YLi ZRuan HLeapman RDLin LNiu GChen XWu A
Adv Mater
2018 Jul 04

Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses.
Mayorova TDSmith CLHammar KWinters CAPivovarova NBAronova MALeapman RDReese TS
PLoS One
2018

Algorithm-driven high-throughput screening of colloidal nanoparticles under simulated physiological and therapeutic conditions.
Bhirde AASindiri SCalco GNAronova MABeaucage SL
Nanoscale
2017 Feb 09

Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures.
Yadav SWilliamson JKAronova MAPrince AAPokrovskaya IDLeapman RDStorrie B
Platelets
2017 Jun

Physicochemical characterization of ferumoxytol, heparin and protamine nanocomplexes for improved magnetic labeling of stem cells.
Bryant LHKim SJHobson MMilo BKovacs ZIJikaria NLewis BKAronova MASousa AAZhang GLeapman RDFrank JA
Nanomedicine
2017 Feb

Compressed Sensing Electron Tomography for Determining Biological Structure.
Guay MDCzaja WAronova MALeapman RD
Sci Rep
2016 Jun 13

DNA-inorganic hybrid nanovaccine for cancer immunotherapy.
Zhu GLiu YYang XKim YHZhang HJia RLiao HSJin ALin JAronova MLeapman RNie ZNiu GChen X
Nanoscale
2016 Mar 28

Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations.
Sousa AAHassan SAKnittel LLBalbo AAronova MABrown PHSchuck PLeapman RD
Nanoscale
2016 Mar 28

Self-organized Mn-Block Copolymer Complexes and Their Use for MR Imaging of Biological Processes.
Pothayee NChen DYAronova MAQian CBouraoud NDodd SLeapman RDKoretsky AP
J Mater Chem B
2014

Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.
Huang PLin JLi WRong PWang ZWang SWang XSun XAronova MNiu GLeapman RDNie ZChen X
Angew Chem Int Ed Engl
2013 Dec 23

Self-assembly of amphiphilic plasmonic micelle-like nanoparticles in selective solvents.
He JHuang XLi YCLiu YBabu TAronova MAWang SLu ZChen XNie Z
J Am Chem Soc
2013 May 29

Cryo-electron tomography of the magnetotactic vibrio Magnetovibrio blakemorei: insights into the biomineralization of prismatic magnetosomes.
Abreu FSousa AAAronova MAKim YCox DLeapman RDAndrade LRKachar BBazylinski DALins U
J Struct Biol
2013 Feb

Elemental mapping by electron energy loss spectroscopy in biology.
Aronova MALeapman RD
Methods Mol Biol
2013

Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.
Xing RZhang FXie JAronova MZhang GGuo NHuang XSun XLiu GBryant LHBhirde ALiang AHou YLeapman RDSun SChen X
Nanoscale
2011 Dec

Manipulating the power of an additional phase: a flower-like Au-Fe3O4 optical nanosensor for imaging protease expressions in vivo.
Xie JZhang FAronova MZhu LLin XQuan QLiu GZhang GChoi KYKim KSun XLee SSun SLeapman RChen X
ACS Nano
2011 Apr 26

Chimeric ferritin nanocages for multiple function loading and multimodal imaging.
Lin XXie JNiu GZhang FGao HYang MQuan QAronova MAZhang GLee SLeapman RChen X
Nano Lett
2011 Feb 09

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast.
Fukunaga MLi TQvan Gelderen Pde Zwart JAShmueli KYao BLee JMaric DAronova MAZhang GLeapman RDSchenck JFMerkle HDuyn JH
Proc Natl Acad Sci U S A
2010 Feb 23

Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors.
Sarin HKanevsky ASWu HSousa AAWilson CMAronova MAGriffiths GLLeapman RDVo HQ
J Transl Med
2009 Jun 23

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells.
Sarin HKanevsky ASWu HBrimacombe KRFung SHSousa AAAuh SWilson CMSharma KAronova MALeapman RDGriffiths GLHall MD
J Transl Med
2008 Dec 18

Localizing specific elements bound to macromolecules by EFTEM.
Leapman RDAronova MA
Methods Cell Biol
2007